Tau is a microtubule-associated protein comprised of six human isoforms predominantly located in the axons of neurons. Neuronal and/or glial inclusions of tau can be detected in several neurodegenerative diseases or “tauopathies”, including Alzheimer’s disease (AD), frontotemporal lobar degeneration (FTLD), Pick’s disease, and cortico-basal degeneration (CBD) and Creutzfeldt-Jakob disease (CJD) may be characterized by their tau isoform profiles.
NEW Antibodies: Brain-derived Tau mAb 2B8 & p50 Tau mAb 15E3
CSF total Tau is a reliable Alzheimer’s disease-specific neurodegeneration marker. In contrast, plasma t-tau concentrations show large overlaps between diagnostic groups and do not correlate with CSF t-tau. Recent studies suggest, that plasma t-tau originates from peripheral, non-brain tissues. (Fernando Gonzalez-Ortiz, et al. Brain-derived tau: a novel blood-based biomarker for Alzheimer’s disease-type neurodegeneration, Brain, Volume 146, Issue 3, March 2023, Pages 1152–1165, https://doi.org/10.1093/brain/awac407)
To solve this problem, we offer our brand-new Anti-human TAU total mab 2B8 that selectively binds to continuous exon 4-5 sequences on brain-derived Tau isoforms, but not to peripheral „Big Tau“ isoforms containing the exon 4a insert.
For more information take a look at this Flyer.
Hyperphosphorylation of the neuronal tau protein is a hallmark of neurodegenerative tauopathies such as Alzheimer’s disease. New research suggests, that a few master phosphorylation sites - T50, T69, T111, T181, and T205 – trigger hyperphosphorylation of tau after they have been initially phosphorylated. (Stefanoska Ket al. Alzheimer's disease: Ablating single master site abolishes tau hyperphosphorylation. Sci Adv. 2022 Jul 8;8(27):eabl8809. doi: 10.1126/sciadv.abl8809)
Our antibody Anti-human phospho-50 TAU mab 15E3 specifically binds human TAU phosphorylated at amino acid position 50 (Thr) and has the potential to distinguish AD from control patients.
For more information take a look at this Flyer.
Sample Applications
Specific detection of P231 tau in astrocytic plaques from Alzheimer's patients using mab 4C10 (G.G. Kovacs, Toronto, Canada).
Specific detection of astrocytic plaques using mab 9D8 in brain of patient with Alzheimers disease (G.G. Kovacs, Toronto, Canada).
Detection of β-amyloid pathological related deposits in Cortex tissue of a patient suffering from Alzheimer’s disease using mab 6D11 (S. Rossner, Leipzig, Germany).
Order information & data sheets
Order number [x] = [1]: 100 μg, [3]: 1 mg | Clon (Datasheet) | Reactivity
|
| Phospho-Tau (Thr50) | ||
| 847-010200800[x] | 15E3 | p50 Tau (Thr50) |
| Phospho-Tau (Thr181) | ||
| 847-010200860[x] | 14B6 | p181 Tau (Thr181) |
| 847-010200930[x] | 7B8 | p181 Tau (Thr181) |
| 847-010200960[x] | 7B9 | p181 Tau (Thr181) |
| Phospho-Tau (Ser199/Ser202) | ||
| 847-010200320[x] | 1F3 | p199 Tau (Ser199) |
| 847-010200460[x] | 9C8 | p199/p202 Tau (Ser199+Ser202) |
| 847-010200450[x] | 10F8 | p202 Tau (Ser202) |
| Phospho-Tau (Thr217) | ||
| 847-010200880[x] | 9G8 | p217Tau (Thr217) |
| Phospho-Tau (Thr231/Ser235) | ||
| 847-010200350[x] | 2B11 | p231Tau (Thr231) |
| 847-010200360[x] | 5G7 | p231Tau (Thr231) |
| 847-010200370[x] | 9D8 | p231Tau (Thr231) |
| 847-010200870[x] | 8G5 | p231Tau (Thr231) |
| 847-010200440[x] | 3G3 | p231/235Tau (Thr231+Ser235) |
| 847-010200910[x] | 5C4 | p231Tau (Thr231) |
| 847-010200920[x] | 6D2 | p231Tau (Thr231) |
| 847-010200940[x] | 7D11 | p231Tau (Thr231) |
| 847-010200950[x] | 2B5 | p231Tau (Thr231) |
| Brain derived Tau | ||
| 847-010200760[x] | 2B8 | Brain-derived Tau |
| Pan-Tau | ||
| 847-010200630[x] | 7E5 | Tau all isoforms |
| 847-010200510[x] | 8F10 | Tau all isoforms |
| Tau Isoforms | ||
| 847-010200640[x] | 2B6 | Exon 3 human Tau |
| 847-010200660[x] | 9E11 | Exon 2 and 3 human Tau |
| Beta-Amyloid | ||
| 847-010200650[x] | 6D11 | Beta-Amyloid N-terminus |
| 847-010200840[x] | 2C7 | Beta-Amyloid 1-12 |
| 847-010200850[x] | 3C4 | Beta-Amyloid 1-12 |
| 847-010200890[x] | 22C2 | Beta-Amyloid 42 |
| 847-010200900[x] | RS-07 | Beta-Amyloid N-terminus |